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   Seminário de Teoria da Computação e Combinatória (TCC)

                 Tarde de Bioinformática
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Título:      The long and the short of RNAs: Complex 
             Processing of ncRNAs
            
Palestrante: Peter F. Stadler 
             Universität Leipzig


Hora e Data: 14h00, segunda-feira, 30 de agosto de 2010

Local:       auditório do NUMEC

Resumo:

Tiling arrays  and more recently  high throughput sequencing
experiments have  revealed a puzzling universe  of short RNA
species that include microRNAs  but are by now means limited
to this  class of key regulators. These  small ncRNAs appear
to be  a highly heterogeneous group, arising  from a diverse
set  of precursors. The  patterns govering  their producting
and  regulation  are  only  emerging at  present.  The  most
abundant subclass  shares some microRNA-like  features: they
are   predominantly   processed   from  heavily   structures
precursors. Conversely, many  of the well-known housekeeping
RNAs, including  snoRNAs, tRNAs, and snRNAs,  are sources of
abundant short RNA fragments.  On the other hand, many types
of  short RNAs  appear unrelated  to structural  features of
their precursors.  Novel and improved  methods computational
methods are  indispensible in  this field, ranging  from the
efficient mapping  of transcriptomics data  to RNA secondary
structure  prediction, efficient structural  alignments, and
machine learning.